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OBJECTIVES: To explore women's understandings of having a mastectomy for screen-detected ductal carcinoma in situ (DCIS).SETTING: Participants recruited throughout the United Kingdom and interviewed in their own homes by an anthropologist.METHODS: Qualitative study using semi-structured interviews and thematic analysis. Thirty-five women with screen-detected DCIS were interviewed, of whom twenty had a mastectomy.RESULTS: A qualitative thematic analysis of women's understandings of having a mastectomy for DCIS identified four key themes: understandings of routine breast screening; uncertainty about DCIS and its natural progression; uncertainty about whether Buy Polo Shirts Online a mastectomy is justified for DCIS; information gaps and treatment decisions. Women were often concerned that a mastectomy for screen-detected DCIS was a 'drastic' treatment for an asymptomatic, precancerous condition of which they had been previously unaware. Some questioned why they were treated with such urgency, even suspecting that their clinicians were responding to targets.CONCLUSION: Given the uncertainties about DCIS and its complexity, it is important that women have the information they need to make treatment decisions. Better information about the uncertainties and the rationale for using mastectomy as a treatment may help women to make better informed choices and feel more comfortable about their decisions.Comment inHow should screeners respond to women's distress about unexpected DCIS uncertainties? [J Med Screen. 2011]How should screeners respond to women's distress about unexpected DCIS uncertainties?Pryke Buy Polo Shirts M, Havercroft D, Bewley S, Blennerhassett M. J Med Screen. 2011; 18(2):104-5; author reply 105-6.